State Street® SPDR® S&P® Biotech ETF

State Street® SPDR® S&P® Biotech ETF

About

State Street® SPDR® S&P® Biotech ETF (US78464A8707) is a US-listed equity ETF tracking the S&P Biotechnology Select Industry Index. With a expense ratio of 0.35%, it is moderately priced, paying distributions. The fund holds 157 positions across 1 region with 10.6B in assets, with heavy concentration — 89% in United States, 89% in Health Care.

Score Breakdown

Scores are scaled 1–10 on a logarithmic curve relative to all ETFs in the database. Last updated: Jul 5, 2026
Component Score Details
Cost (30%) 8.0 Tracking Difference: 10.0 · TD Consistency: — · Expense Ratio: 3.3
Liquidity (25%) 10.0 Assets Under Management

Data sources: provider factsheets, exchange data, and NAV history. Information for educational purposes only — not investment advice.

ISIN
Fund Size $10.6B
Issuer SPDR
Distribution Pays Distributions
Replication Physical
Inception Jan 2006
Base Currency USD
Index S&P Biotechnology Select Industry Index
Asset Class Equities
Category Thematic Equity

Costs

8.0
This fund has low total costs, with competitive tracking and expense ratios.

Cost Metrics Explained

What expense ratio, tracking difference, and TD consistency measure

Expense ratio (Total Expense Ratio) is the annual fee the fund charges, deducted from assets. It’s the headline cost, but not the full picture.

Tracking Difference measures how much the fund actually lags (or leads) its benchmark index per year. This is the single best measure of true cost — it captures the expense ratio plus all other drags like sampling error and tax withholding. A lower (or negative) value is better.

TD Consistency measures how stable the tracking difference is from year to year. A low value means predictable, reliable costs; a high value means costs can vary significantly.
Expense Ratio0.00%
 
Metric Value
Expense Ratio 0.35%

Cumulative Returns

Performance across different time periods.
1 Month+0.00%
3 Months+0.00%
Year to Date+0.00%
1 Year+0.00%
3 Years+0.00%
5 Years+0.00%
Inception+0.00%
 
Period Cumulative Return
1 Month +4.14%
3 Months +0.21%
6 Months +0.29%
1 Year +73.29%
3 Years +17.78%
5 Years +1.45%
10 Years +9.10%
YTD +12.11%
Since Inception +11.24%

Holdings

4.8
With only 157 individual holdings, this fund is relatively concentrated compared to other ETFs.
#1
A
Apogee Therapeutics Inc
1.51%
#2
M
Moderna Inc
1.48%
#3
T
Twist Bioscience Corp
1.41%
#4
K
Kymera Therapeutics Inc
1.37%
#5
O
Oruka Therapeutics Inc
1.37%
#6
V
Viking Therapeutics Inc
1.27%
#7
E
Erasca Inc
1.26%
#8
P
Praxis Precision Medicines Inc
1.25%
#9
R
REVOLUTION Medicines Inc
1.22%
#10
C
CG oncology Inc
1.21%

Sectors

Allocation by industry sector.
 
Sector Weight
Health Care 8948.00%
Unknown 1052.00%

Regions

Geographic allocation by country of risk.
 
Country Weight
United States 8948.00%
UNKNOWN 1052.00%

Documents

Regulatory and fund documents.
Fact Sheet

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