State Street® SPDR® S&P® Pharmaceuticals ETF
State Street® SPDR® S&P® Pharmaceuticals ETF
About
State Street® SPDR® S&P® Pharmaceuticals ETF (US78464A7220) is a US-listed physically replicated equity ETF tracking the S&P Pharmaceuticals Select Industry Index. With a expense ratio of 0.35%, it is moderately priced, paying distributions. The fund holds 66 positions across 1 region with 464M in assets, with heavy concentration — 79% in United States, 79% in Health Care, launched in 2006. Over the past year, the fund returned 44.6%. We rate this fund 5.7/10.
5.7
5.7
- 21%Tracking Difference10.0
- TD Consistency—
- 9%Expense Ratio3.3
- 11.25%Holding Count3.5
- 22.5%Country Concentration4.8
- 11.25%Sector Concentration1.0
- 25%Assets Under Management6.8
Scores are scaled 1–10 on a logarithmic curve relative to all ETFs in the database. Data sources: provider factsheets, exchange data, and NAV history. Information for educational purposes only — not investment advice. Last updated: Jul 14, 2026
Ticker XPH
ISIN
Fund Size $463.9M
Issuer SPDR
Distribution Pays Distributions
Replication Physical
Inception Jun 2006
Base Currency USD
Index S&P Pharmaceuticals Select Industry Index
Asset Class Equities
Category Equity Sector
Costs
8.0 This fund has low total costs, with competitive tracking and expense ratios.
Expense Ratio0.35%
Expense Ratio0.35%
| Metric | Value |
|---|---|
| Expense Ratio | 0.35% |
Cumulative Returns
Performance across different time periods.
1 Month+1.09%
3 Months+0.25%
Year to Date+4.11%
1 Year+44.61%
3 Years+15.34%
5 Years+4.24%
Inception+8.56%
1 Month+1.09%
3 Months+0.25%
Year to Date+4.11%
1 Year+44.61%
3 Years+15.34%
5 Years+4.24%
Inception+8.56%
| Period | Cumulative Return |
|---|---|
| 1 Month | +1.09% |
| 3 Months | +0.25% |
| 6 Months | +0.24% |
| 1 Year | +44.61% |
| 3 Years | +15.34% |
| 5 Years | +4.24% |
| 10 Years | +3.96% |
| YTD | +4.11% |
| Since Inception | +8.56% |
Holdings
3.5 With only 66 individual holdings, this fund is relatively concentrated compared to other ETFs.
| Holding | Weight |
|---|---|
| DEFINIUM THERAPEUTICS INC | 2.88% |
| MBX Biosciences Inc | 2.81% |
| Alumis Inc | 2.05% |
| Enliven Therapeutics Inc | 2.04% |
| Trevi Therapeutics Inc | 2.02% |
| Amylyx Pharmaceuticals Inc | 2.01% |
| MAZE THERAPEUTICS INC | 1.98% |
| VERADERMICS INC | 1.98% |
| AtaiBeckley Inc | 1.98% |
| Ligand Pharmaceuticals Inc | 1.95% |
| Nektar Therapeutics | 1.94% |
| Harrow Inc | 1.89% |
| Crinetics Pharmaceuticals Inc | 1.85% |
Sectors
1.0 This fund is concentrated in just a few of its 2 sectors, reducing diversification.
| Sector | Weight |
|---|---|
| Health Care | 78.59% |
| Unknown | 21.41% |
Regions
4.8 This fund is concentrated in just 2 countries, with significant geographic concentration.
| Country | Weight |
|---|---|
| United States | 78.59% |
| UNKNOWN | 21.41% |
Nerd Stuff
Advanced risk and return metrics (17 July 2023 — 7 July 2026).
20.2%
Volatility
-24.0%
Max Drawdown
0.86
Sharpe Ratio
1.25
Sortino Ratio
0.72
Calmar Ratio
0.23
Beta
12.65%
Alpha (Jensen's)
0.033
R²
Benchmark-relative metrics (Beta, Alpha, R²) are calculated against the iShares Core S&P 500 ETF (IE00B5BMR087).
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