iShares Neuroscience and Healthcare ETF

iShares Neuroscience and Healthcare ETF

About

iShares Neuroscience and Healthcare ETF (US46436E3532) is a US-listed equity ETF tracking the NYSE FactSet Global Neuro Biopharma and MedTech Index (USD) (Net). With a expense ratio of 0.47%, its costs are on the higher end for an ETF, paying distributions. The fund holds 86 positions across 9 regions with 5M in assets, with heavy concentration — 72% in United States, 84% in Health Care.

Score Breakdown

Scores are scaled 1–10 on a logarithmic curve relative to all ETFs in the database. Last updated: Jun 22, 2026
Component Score Details
Cost (30%) 7.7 Tracking Difference: 10.0 · TD Consistency: — · Expense Ratio: 2.2
Liquidity (25%) 2.5 Assets Under Management

Data sources: provider factsheets, exchange data, and NAV history. Information for educational purposes only — not investment advice.

Ticker IBRN
ISIN
Fund Size $5.4M
Issuer iShares
Distribution Pays Distributions
Replication Physical
Inception Aug 2022
Base Currency USD
Index NYSE FactSet Global Neuro Biopharma and MedTech Index (USD) (Net)
Asset Class Equities

Costs

7.7
This fund has low total costs, with competitive tracking and expense ratios.

Cost Metrics Explained

What expense ratio, tracking difference, and TD consistency measure

Expense ratio (Total Expense Ratio) is the annual fee the fund charges, deducted from assets. It’s the headline cost, but not the full picture.

Tracking Difference measures how much the fund actually lags (or leads) its benchmark index per year. This is the single best measure of true cost — it captures the expense ratio plus all other drags like sampling error and tax withholding. A lower (or negative) value is better.

TD Consistency measures how stable the tracking difference is from year to year. A low value means predictable, reliable costs; a high value means costs can vary significantly.

Expense Ratio0.00%
 
Metric Value
Expense Ratio 0.47%

Cumulative Returns

Performance across different time periods.
Year to Date+0.00%
1 Year+0.00%
3 Years+0.00%
Inception+0.00%
 
Period Cumulative Return
1 Month
3 Months
6 Months
1 Year +65.10%
3 Years +14.58%
5 Years
10 Years
YTD +11.00%
Since Inception +10.17%

Holdings

This fund invests into 86 individual investments.
#1
Arrowhead Pharmaceuticals Inc
4.27%
#2
PTC Therapeutics Inc
4.25%
#3
Praxis Precision Medicines Inc
4.24%
#4
Axsome Therapeutics Inc
4.11%
#5
Scholar Rock Holding Corp
4.08%
#6
Alkermes PLC
4.01%
#7
Dianthus Therapeutics Inc
3.91%
#8
Xenon Pharmaceuticals Inc
3.90%
#9
CENTESSA PHARMACEUTICALS AMERICAN
3.86%
#10
Biogen Inc
3.84%
View all holdings (50)
# Holding Ticker Weight
1 Arrowhead Pharmaceuticals Inc ARWR 426.90%
2 PTC Therapeutics Inc PTCT 424.57%
3 Praxis Precision Medicines Inc PRAX 423.77%
4 Axsome Therapeutics Inc AXSM 411.43%
5 Scholar Rock Holding Corp SRRK 407.53%
6 Alkermes PLC ALKS 400.93%
7 Dianthus Therapeutics Inc DNTH 390.81%
8 Xenon Pharmaceuticals Inc XENE 390.12%
9 CENTESSA PHARMACEUTICALS AMERICAN CNTA 386.05%
10 Biogen Inc BIIB 383.94%
11 ARGENX SE - ADR ARGX 375.50%
12 ACADIA Pharmaceuticals Inc ACAD 372.07%
13 Neurocrine Biosciences Inc NBIX 368.33%
14 Catalyst Pharmaceuticals Inc CPRX 356.64%
15 Denali Therapeutics Inc DNLI 353.11%
16 Edgewise Therapeutics Inc EWTX 294.08%
17 Dyne Therapeutics Inc DYN 266.13%
18 Supernus Pharmaceuticals Inc SUPN 245.75%
19 Axogen Inc AXGN 236.12%
20 SK Biopharmaceuticals Co Ltd 326030 226.69%
21 Sarepta Therapeutics Inc SRPT 180.74%
22 Biohaven Ltd BHVN 173.33%
23 H Lundbeck A/S HLUN B 173.17%
24 Taysha Gene Therapies Inc TSHA 153.70%
25 Capricor Therapeutics Inc CAPR 151.13%
26 BioArctic AB BIOA B 135.77%
27 Idorsia Ltd IDIA 127.22%
28 Integra LifeSciences Holdings Corp IART 118.31%
29 Rapport Therapeutics Inc RAPP 108.14%
30 Neuren Pharmaceuticals Ltd NEU 99.97%
31 ALTO NEUROSCIENCE INC ANRO 72.67%
32 Annexon Inc ANNX 71.10%
33 Dynavox Group AB DYVOX 66.85%
34 SOLID BIOSCIENCES INC SLDB 66.35%
35 USD CASH USD 66.06%
36 Medincell SA MEDCL 65.71%
37 LB Pharmaceuticals Inc LBRX 63.45%
38 RELMADA THERAPEUTICS INC RLMD 58.15%
39 CLEARPOINT NEURO INC CLPT 49.32%
40 DESIGN THERAPEUTICS INC DSGN 47.71%
41 BRIGHT MINDS BIOSCIENCES INC DRUG 46.83%
42 MICROPORT NEUROTECH CORP 2172 45.29%
43 CERIBELL INC CBLL 44.84%
44 BRAINSWAY ADR REPRESENTING LTD BWAY 44.70%
45 PROTHENA PLC PRTA 42.09%
46 ONCOLYS BIOPHARMA INC 4588 41.86%
47 NEUROPACE INC NPCE 40.64%
48 BENITEC BIOPHARMA INC BNTC 40.63%
49 NEUROGENE INC NGNE 39.76%
50 OVID THERAPEUTICS INC OVID 38.71%

Sectors

Allocation by industry sector.
 
Sector Weight
Health Care 8414.00%
Unknown 1519.00%
Technology 67.00%

Regions

Geographic allocation by country of risk.
 
Country Weight
United States 7172.00%
UNKNOWN 1518.00%
Netherlands 376.00%
South Korea 227.00%
Sweden 203.00%
Denmark 173.00%
Switzerland 127.00%
Australia 100.00%
France 66.00%
Japan 38.00%
Feedback
ETFs
Basket
Compare