State Street® SPDR® S&P® Pharmaceuticals ETF

State Street® SPDR® S&P® Pharmaceuticals ETF

About

State Street® SPDR® S&P® Pharmaceuticals ETF (US78464A7220) is a US-listed equity ETF tracking the S&P Pharmaceuticals Select Industry Index. With a expense ratio of 0.35%, it is moderately priced, paying distributions. The fund holds 66 positions across 1 region with 422M in assets, with heavy concentration — 79% in United States, 79% in Health Care.

Score Breakdown

Scores are scaled 1–10 on a logarithmic curve relative to all ETFs in the database. Last updated: Jul 5, 2026
Component Score Details
Cost (30%) 8.0 Tracking Difference: 10.0 · TD Consistency: — · Expense Ratio: 3.3
Liquidity (25%) 6.8 Assets Under Management

Data sources: provider factsheets, exchange data, and NAV history. Information for educational purposes only — not investment advice.

ISIN
Fund Size $421.9M
Issuer SPDR
Distribution Pays Distributions
Replication Physical
Inception Jun 2006
Base Currency USD
Index S&P Pharmaceuticals Select Industry Index
Asset Class Equities
Category Equity Sector

Costs

8.0
This fund has low total costs, with competitive tracking and expense ratios.

Cost Metrics Explained

What expense ratio, tracking difference, and TD consistency measure

Expense ratio (Total Expense Ratio) is the annual fee the fund charges, deducted from assets. It’s the headline cost, but not the full picture.

Tracking Difference measures how much the fund actually lags (or leads) its benchmark index per year. This is the single best measure of true cost — it captures the expense ratio plus all other drags like sampling error and tax withholding. A lower (or negative) value is better.

TD Consistency measures how stable the tracking difference is from year to year. A low value means predictable, reliable costs; a high value means costs can vary significantly.
Expense Ratio0.00%
 
Metric Value
Expense Ratio 0.35%

Cumulative Returns

Performance across different time periods.
1 Month+0.00%
3 Months+0.00%
Year to Date+0.00%
1 Year+0.00%
3 Years+0.00%
5 Years+0.00%
Inception+0.00%
 
Period Cumulative Return
1 Month +1.09%
3 Months +0.20%
6 Months +0.18%
1 Year +44.61%
3 Years +15.34%
5 Years +4.24%
10 Years +3.96%
YTD +4.11%
Since Inception +8.56%

Holdings

3.3
With only 66 individual holdings, this fund is relatively concentrated compared to other ETFs.
#1
D
DEFINIUM THERAPEUTICS INC
2.89%
#2
M
MBX Biosciences Inc
2.80%
#3
V
VERADERMICS INC
2.14%
#4
A
Amylyx Pharmaceuticals Inc
2.07%
#5
A
Alumis Inc
2.06%
#6
E
Enliven Therapeutics Inc
2.04%
#7
T
Trevi Therapeutics Inc
2.04%
#8
A
AtaiBeckley Inc
2.00%
#9
L
Ligand Pharmaceuticals Inc
1.95%
#10
L
Liquidia Corp
1.88%

Sectors

Allocation by industry sector.
 
Sector Weight
Health Care 7857.00%
Unknown 2143.00%

Regions

Geographic allocation by country of risk.
 
Country Weight
United States 7857.00%
UNKNOWN 2143.00%

Documents

Regulatory and fund documents.
Fact Sheet

Similar ETFs

Other funds tracking Equity Sector indices.
State Street® Technology Select Sector SPDR® ETF
US81369Y8030·Expense Ratio 0.08%
State Street® Financial Select Sector SPDR® ETF
US81369Y6059·Expense Ratio 0.08%
State Street® SPDR® Dow Jones Industrial Average® ETF Trust
US78467X1090·Expense Ratio 0.16%
State Street® Health Care Select Sector SPDR® ETF
US81369Y2090·Expense Ratio 0.08%
State Street® Energy Select Sector SPDR® ETF
US81369Y5069·Expense Ratio 0.08%
State Street® Industrial Select Sector SPDR® ETF
US81369Y7040·Expense Ratio 0.08%
Feedback
ETFs
Basket
Compare